This research was conducted at the Hadassah Medical Center (Jerusalem, Israel) during Summer 2022.
This abstract was previously published in the Stern College “Women in Science” Journal.
Title: The Effect of Glial Activation and Depression in Wild Type and Transgenic Mice.
Topic: Biology – Alzheimer’s and Depression.
SUMMARY:
Under the supervision of Dr. Lotan at the Laboratory of Biological Psychiatry at Hadassah Medical Center, we investigated the mechanisms that connect Alzheimer’s Disease and Major Depressive Disorder. In order to explore this connection, we conducted behavioral tests on wild-type and transgenic mice to study the effect of glial activation in mice, and determine whether neuroinflammation is a link between Alzheimer’s and depression.
Stern College for Women, Yeshiva University
This research was done under the mentorship of Dr. Jonathan Feldman at Yeshiva University’s Ferkauf Graduate School of Psychology.
Title: Inflammatory and Behavioral Pathways Involved in Depression in Older Asthmatics.
Keywords: Asthma, Depression.
SUMMARY:
This longitudinal study of older asthma patients examines the role of Major Depression (MD) in asthma outcomes, and identifies two potential pathways linking them- systemic and airway inflammation, as well as illness and medication beliefs which may lead to different Self-Management Behaviors (SMB).
ABSTRACT
This longitudinal study examines older asthma patients at six month intervals over the course of 18 months to detect the presence of Major Depression (MD), inflammatory markers, Self- Management Behaviors (SMB), and to examine asthma outcomes. The first aim of the study is to determine the relationship of MD with airway and systemic inflammation in this population, as well as to evaluate the longitudinal association with outcomes. It is hypothesized that older asthma patients with MD will have increased airway and systemic inflammation; it is also hypothesized that increased airway inflammation in older patients with MD will be associated with worse asthma control over time. The second aim of the study is to establish longitudinal association between MD and adherence to asthma SMB in this population and to identify pathways linking them. It is hypothesized that older asthma patients with MD will have lower adherence to SMB; it is also hypothesized that views of asthma as an acute disease, low self-efficacy for asthma management, heightened emotional responses to asthma (i.e., catastrophizing), and increased concerns about asthma medications will mediate, in part, the influence of MD on SMB.
Music Research Paper - ABSTRACT:
Immigration to America not only influenced, but shaped the sounds of film music. Some of the first studios were founded by immigrants – Paramount Pictures, for example, was founded by a Jewish immigrant. Many composers came to the United States and eventually made their way to Hollywood to work on films. Franz Waxman, Max Steiner, Miklós Rózsa, and Erich Wolfgang Korngold are all examples of immigrants who composed film music. Throughout this paper, through biographical research, I examine their lives and what shaped them to become the composers they were. Specifically, I document how their culture influenced them, what their music sounds like, and the relationship between these two factors.
Additionally, in this paper, I examine the ability of music to express that which the composer wishes to express. I explain how film music can bolster a scene, as well as how moviegoers have come to understand certain troupes or feelings based on the sounds they hear. As certain notes or tones were used to represent different events or feelings in a picture, people grew accustomed to feeling an emotion when they heard a certain sound. I examine this in my analysis of a few film scores by the immigrants mentioned above.
Waxman, Steiner, Rózsa, and Korngold all brought their experiences to America; the cultures of their youth and their memories are portrayed through their music. This paper examines their lives and the musical choices they made in light of their status as immigrants.
Title: Immigration to America and Its Influence on Film Music and its Composers.
Topic: Music History – Early Film Music and the Influence of Immigration on Film Music.
SUMMARY:
Early film music in the United States was largely influenced by immigration. Franz Waxman, Max Steiner, Miklós Rózsa, and Erich Wolfgang Korngold are composers who worked on film music and whose music was influenced by their culture. In this paper I examine these individuals, study the choices they made in the music industry in light of their immigration statuses, and analyze some of their music.
Yeshiva College, Yeshiva University,
Class of 2024
Title: A Study of interaction between KRAS and SMARCA4 (Brg-1) protein in Human colorectal carcinoma cell lines.
Topic: Biology.
SUMMARY:
The aim of this experiment was to determine if the oncogene KRAS binds to and regulates SMARCA4 function. It was found that in the Brg-1 knocked-down cell lines PRMT5 was upregulated and KRAS3 was downregulated, and so it would appear that the oncogene KRAS binds to and regulates SMARCA4 function.
ABSTRACT:
The aim of this experiment was to determine if the oncogene KRAS (Kirsten rat sarcoma viral oncogene homolog) binds to and regulates SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) function. We used the human colorectal cancer cell lines HKE3, a KRAS wt, and HCT116, a KRAS mutant cell line. Brg-1 shRNA was applied to knock down SMARCA4, and knock down of gene was confirmed by western blot. Quantification of multiple gene's expression was performed by qRTPCR in knocked down cells compared to wide type. It was found that in the knocked-down cell lines, PRMT5 was upregulated and KRAS3 was downregulated. It would appear from the results that the oncogene KRAS does bind to and regulate SMARCA4 function." Our hypothesis could help create a SMARCA4 targeted therapy for colorectal cancers expressing KRAS.
ABSTRACT:
Psychedelic research on psychedelic drug treatment has recently gained a renewed interest in the field of mental health as a potential treatment for a variety of disorders including anxiety, depression, and PTSD. Minimal research exists studying the efficacy of psychedelic-assisted therapy (PAT) in the treatment of Eating Disorders (ED), a disorder that is so difficult to treat and affects the lives of so many people. This paper explores the current research on the use of psychedelics in the treatment of eating disorders, including anorexia nervosa, bulimia nervosa, and binge eating disorder. The mechanisms behind the potential effectiveness of psychedelics in treating eating disorders will be examined, as well as any potential risks or limitations of this approach. Ultimately, this paper aims to provide a comprehensive review of the current literature surrounding the use of psychedelics in the treatment of eating . The findings suggest that, although further research is necessary, there is reason for optimism regarding the future of Eating Disorder treatment. PAT provides an outlet to reframe ED patients’ minds and habits and create new pathways that can be beneficial in treatment. Further research should address concerns such as cost, effectiveness, and use of control groups. There is hope that more findings will emerge and PAT may be the next emerging treatment for EDs.
SUMMARY:
The entire world is talking about psychedelics. Which one is the most harmful? Which one is the most common amongst college kids and what are we going to do about it? Or which one is going to help us have the best time at the rave? The world of psychedelic research is taking a different stance to explore these substances. This paper explores the use of various psychedelics as a potential treatment for eating disorders. The hypotheses are based on previous research and the connections that eating disorders have to other disorders that have been treated with psychedelics as well as overlap between eating disorder symptoms and psychedelic reactions.
This research paper received the Monis and Chaya Zuckerman Memorial Award for best research paper in Jewish History (May 2023).
Title: “Uncovering an Antisemitic Past: Jewish Integration to Costa Rica from 1930-1970.”
Keywords: Jewish, Costa Rica, Discrimination, Nationalism, Antisemitism, Xenophobia, Diaspora, Immigration.
ABSTRACT:
During the 20th century Costa Rica experienced a mass migration of European Jews in search of refuge from the increasing poverty, discrimination, violence and religous persecution resulting from World War II. The process of integration of these Jewish refugees — who were often characterized by their nonconformist qualities — to the Costa Rican population that exacted conformity as the price of acceptance, was faced with various challenges. The main contributor to the adversity the Jews faced was the nationalism, xenophobia and fear of competition of Costa Ricans throughout this period. As consequence of this ongoing discrimination, the stories of the Jewish migrants have been systematically absent regardless of the important contributions made by Jews and the crucial roles they have played in the country’s history. Through in-depth investigation and examination of archives, recorded demographics, news reports, interviews and books written by Jewish migrants, this thesis analyzes the difficulties these immigrants encountered during the Jewish diaspora in Costa Rica. Studying the xenophobia Jews experienced in their integration to Costa Rica provides a blueprint on how to prevent other marginalized and immigrant communities from enduring similar discrimination.
Yosef is an author on “Message in a Bottle – An Update to the Golden Record” (https://arxiv.org/abs/2306.01765; to appear in Nature Communications).
Keywords: NASA Jet Propulsion Laboratory (JPL), computers and society, physics and society, physics education.
ABSTRACT:
Communication is an essential asset enabling humankind to forge an advanced civilization. Using approximately 31,000 languages from the Stone Age to our present digital information society, humans have connected and collaborated to accomplish remarkable feats. As the newly dawned Space Age progresses, we are attempting to communicate with intelligent species beyond our world, on distant planets and in Earth's far future. Absent mutually understood signs, symbols, and semiotic conventions, this study, the "Message in a Bottle", uses scientific methods to assess and design a means of communication encapsulating the story of humanity, conveying our thoughts, emotions, ingenuity, and aspirations. The message will be structured to provide a universal yet contextual understanding of modern human society, evolution of life on Earth, and challenges for the future. In assembling this space and time capsule, we aim to energize and unite current generations to celebrate and preserve humanity.
In University of Cambridge’s Fragment of the Month series, Yosef authored “New Pages of Sefer Tagin: JTS ENA 2753.16 and National Library of Russia (NLR) Box N.91” (April 2023).
Keywords: Cairo Geniza, Hebrew manuscript fragments, Sefer Tagin.
ABSTRACT:
Sefer Tagin is an ancient treatise which lists out certain letters, called Otiyyot Meshunnot, that should be written in Torah scrolls in a strange or unusual manner, often by adding little crownlets (Tagin) or whorls to them. Unfortunately, the work was preserved very poorly, and almost no copies of the complete text survive: for example, the editio princeps, published only in 1866, is riddled with errors. So little is known about the text that scholars in the modern day have been forced to try and cobble together some sort of urtext, piecemeal, from bits of manuscript and quotation, but comparing the text between the different textual witnesses that have survived, most of which are relatively late, reveals extraordinary variation. This is what makes Genizah fragments of Sefer Tagin, many of which have been described in previous research, so important. In this paper, two new manuscript pages of Sefer Tagin, JTS ENA 2753.16 and NLR Box N.91, are introduced, transcribed, and analyzed.
This research was conducted at the Hadassah Medical Center (Jerusalem, Israel) during Summer 2022.
This abstract was previously published in the Stern College “Women in Science” Journal.
Title: The Effect of Glial Activation and Depression in Wild Type and Transgenic Mice.
Topic: Biology – Alzheimer’s and Depression.
SUMMARY:
Under the supervision of Dr. Lotan at the Laboratory of Biological Psychiatry at Hadassah Medical Center, we investigated the mechanisms that connect Alzheimer’s Disease and Major Depressive Disorder. In order to explore this connection, we conducted behavioral tests on wild-type and transgenic mice to study the effect of glial activation in mice, and determine whether neuroinflammation is a link between Alzheimer’s and depression.
Stern College for Women, Yeshiva University
This research was done under the mentorship of Dr. Jonathan Feldman at Yeshiva University’s Ferkauf Graduate School of Psychology.
Title: Inflammatory and Behavioral Pathways Involved in Depression in Older Asthmatics.
Keywords: Asthma, Depression.
SUMMARY:
This longitudinal study of older asthma patients examines the role of Major Depression (MD) in asthma outcomes, and identifies two potential pathways linking them- systemic and airway inflammation, as well as illness and medication beliefs which may lead to different Self-Management Behaviors (SMB).
ABSTRACT
This longitudinal study examines older asthma patients at six month intervals over the course of 18 months to detect the presence of Major Depression (MD), inflammatory markers, Self- Management Behaviors (SMB), and to examine asthma outcomes. The first aim of the study is to determine the relationship of MD with airway and systemic inflammation in this population, as well as to evaluate the longitudinal association with outcomes. It is hypothesized that older asthma patients with MD will have increased airway and systemic inflammation; it is also hypothesized that increased airway inflammation in older patients with MD will be associated with worse asthma control over time. The second aim of the study is to establish longitudinal association between MD and adherence to asthma SMB in this population and to identify pathways linking them. It is hypothesized that older asthma patients with MD will have lower adherence to SMB; it is also hypothesized that views of asthma as an acute disease, low self-efficacy for asthma management, heightened emotional responses to asthma (i.e., catastrophizing), and increased concerns about asthma medications will mediate, in part, the influence of MD on SMB.
Music Research Paper - ABSTRACT:
Immigration to America not only influenced, but shaped the sounds of film music. Some of the first studios were founded by immigrants – Paramount Pictures, for example, was founded by a Jewish immigrant. Many composers came to the United States and eventually made their way to Hollywood to work on films. Franz Waxman, Max Steiner, Miklós Rózsa, and Erich Wolfgang Korngold are all examples of immigrants who composed film music. Throughout this paper, through biographical research, I examine their lives and what shaped them to become the composers they were. Specifically, I document how their culture influenced them, what their music sounds like, and the relationship between these two factors.
Additionally, in this paper, I examine the ability of music to express that which the composer wishes to express. I explain how film music can bolster a scene, as well as how moviegoers have come to understand certain troupes or feelings based on the sounds they hear. As certain notes or tones were used to represent different events or feelings in a picture, people grew accustomed to feeling an emotion when they heard a certain sound. I examine this in my analysis of a few film scores by the immigrants mentioned above.
Waxman, Steiner, Rózsa, and Korngold all brought their experiences to America; the cultures of their youth and their memories are portrayed through their music. This paper examines their lives and the musical choices they made in light of their status as immigrants.
Title: Immigration to America and Its Influence on Film Music and its Composers.
Topic: Music History – Early Film Music and the Influence of Immigration on Film Music.
SUMMARY:
Early film music in the United States was largely influenced by immigration. Franz Waxman, Max Steiner, Miklós Rózsa, and Erich Wolfgang Korngold are composers who worked on film music and whose music was influenced by their culture. In this paper I examine these individuals, study the choices they made in the music industry in light of their immigration statuses, and analyze some of their music.
Yeshiva College, Yeshiva University,
Class of 2024
Title: A Study of interaction between KRAS and SMARCA4 (Brg-1) protein in Human colorectal carcinoma cell lines.
Topic: Biology.
SUMMARY:
The aim of this experiment was to determine if the oncogene KRAS binds to and regulates SMARCA4 function. It was found that in the Brg-1 knocked-down cell lines PRMT5 was upregulated and KRAS3 was downregulated, and so it would appear that the oncogene KRAS binds to and regulates SMARCA4 function.
ABSTRACT:
The aim of this experiment was to determine if the oncogene KRAS (Kirsten rat sarcoma viral oncogene homolog) binds to and regulates SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) function. We used the human colorectal cancer cell lines HKE3, a KRAS wt, and HCT116, a KRAS mutant cell line. Brg-1 shRNA was applied to knock down SMARCA4, and knock down of gene was confirmed by western blot. Quantification of multiple gene's expression was performed by qRTPCR in knocked down cells compared to wide type. It was found that in the knocked-down cell lines, PRMT5 was upregulated and KRAS3 was downregulated. It would appear from the results that the oncogene KRAS does bind to and regulate SMARCA4 function." Our hypothesis could help create a SMARCA4 targeted therapy for colorectal cancers expressing KRAS.
ABSTRACT:
Psychedelic research on psychedelic drug treatment has recently gained a renewed interest in the field of mental health as a potential treatment for a variety of disorders including anxiety, depression, and PTSD. Minimal research exists studying the efficacy of psychedelic-assisted therapy (PAT) in the treatment of Eating Disorders (ED), a disorder that is so difficult to treat and affects the lives of so many people. This paper explores the current research on the use of psychedelics in the treatment of eating disorders, including anorexia nervosa, bulimia nervosa, and binge eating disorder. The mechanisms behind the potential effectiveness of psychedelics in treating eating disorders will be examined, as well as any potential risks or limitations of this approach. Ultimately, this paper aims to provide a comprehensive review of the current literature surrounding the use of psychedelics in the treatment of eating . The findings suggest that, although further research is necessary, there is reason for optimism regarding the future of Eating Disorder treatment. PAT provides an outlet to reframe ED patients’ minds and habits and create new pathways that can be beneficial in treatment. Further research should address concerns such as cost, effectiveness, and use of control groups. There is hope that more findings will emerge and PAT may be the next emerging treatment for EDs.
SUMMARY:
The entire world is talking about psychedelics. Which one is the most harmful? Which one is the most common amongst college kids and what are we going to do about it? Or which one is going to help us have the best time at the rave? The world of psychedelic research is taking a different stance to explore these substances. This paper explores the use of various psychedelics as a potential treatment for eating disorders. The hypotheses are based on previous research and the connections that eating disorders have to other disorders that have been treated with psychedelics as well as overlap between eating disorder symptoms and psychedelic reactions.
This research paper received the Monis and Chaya Zuckerman Memorial Award for best research paper in Jewish History (May 2023).
Title: “Uncovering an Antisemitic Past: Jewish Integration to Costa Rica from 1930-1970.”
Keywords: Jewish, Costa Rica, Discrimination, Nationalism, Antisemitism, Xenophobia, Diaspora, Immigration.
ABSTRACT:
During the 20th century Costa Rica experienced a mass migration of European Jews in search of refuge from the increasing poverty, discrimination, violence and religous persecution resulting from World War II. The process of integration of these Jewish refugees — who were often characterized by their nonconformist qualities — to the Costa Rican population that exacted conformity as the price of acceptance, was faced with various challenges. The main contributor to the adversity the Jews faced was the nationalism, xenophobia and fear of competition of Costa Ricans throughout this period. As consequence of this ongoing discrimination, the stories of the Jewish migrants have been systematically absent regardless of the important contributions made by Jews and the crucial roles they have played in the country’s history. Through in-depth investigation and examination of archives, recorded demographics, news reports, interviews and books written by Jewish migrants, this thesis analyzes the difficulties these immigrants encountered during the Jewish diaspora in Costa Rica. Studying the xenophobia Jews experienced in their integration to Costa Rica provides a blueprint on how to prevent other marginalized and immigrant communities from enduring similar discrimination.
Yosef is an author on “Message in a Bottle – An Update to the Golden Record” (https://arxiv.org/abs/2306.01765; to appear in Nature Communications).
Keywords: NASA Jet Propulsion Laboratory (JPL), computers and society, physics and society, physics education.
ABSTRACT:
Communication is an essential asset enabling humankind to forge an advanced civilization. Using approximately 31,000 languages from the Stone Age to our present digital information society, humans have connected and collaborated to accomplish remarkable feats. As the newly dawned Space Age progresses, we are attempting to communicate with intelligent species beyond our world, on distant planets and in Earth's far future. Absent mutually understood signs, symbols, and semiotic conventions, this study, the "Message in a Bottle", uses scientific methods to assess and design a means of communication encapsulating the story of humanity, conveying our thoughts, emotions, ingenuity, and aspirations. The message will be structured to provide a universal yet contextual understanding of modern human society, evolution of life on Earth, and challenges for the future. In assembling this space and time capsule, we aim to energize and unite current generations to celebrate and preserve humanity.
In University of Cambridge’s Fragment of the Month series, Yosef authored “New Pages of Sefer Tagin: JTS ENA 2753.16 and National Library of Russia (NLR) Box N.91” (April 2023).
Keywords: Cairo Geniza, Hebrew manuscript fragments, Sefer Tagin.
ABSTRACT:
Sefer Tagin is an ancient treatise which lists out certain letters, called Otiyyot Meshunnot, that should be written in Torah scrolls in a strange or unusual manner, often by adding little crownlets (Tagin) or whorls to them. Unfortunately, the work was preserved very poorly, and almost no copies of the complete text survive: for example, the editio princeps, published only in 1866, is riddled with errors. So little is known about the text that scholars in the modern day have been forced to try and cobble together some sort of urtext, piecemeal, from bits of manuscript and quotation, but comparing the text between the different textual witnesses that have survived, most of which are relatively late, reveals extraordinary variation. This is what makes Genizah fragments of Sefer Tagin, many of which have been described in previous research, so important. In this paper, two new manuscript pages of Sefer Tagin, JTS ENA 2753.16 and NLR Box N.91, are introduced, transcribed, and analyzed.
This research was conducted at the Hadassah Medical Center (Jerusalem, Israel) during Summer 2022.
This abstract was previously published in the Stern College “Women in Science” Journal.
Title: The Effect of Glial Activation and Depression in Wild Type and Transgenic Mice.
Topic: Biology – Alzheimer’s and Depression.
SUMMARY:
Under the supervision of Dr. Lotan at the Laboratory of Biological Psychiatry at Hadassah Medical Center, we investigated the mechanisms that connect Alzheimer’s Disease and Major Depressive Disorder. In order to explore this connection, we conducted behavioral tests on wild-type and transgenic mice to study the effect of glial activation in mice, and determine whether neuroinflammation is a link between Alzheimer’s and depression.
Stern College for Women, Yeshiva University
This research was done under the mentorship of Dr. Jonathan Feldman at Yeshiva University’s Ferkauf Graduate School of Psychology.
Title: Inflammatory and Behavioral Pathways Involved in Depression in Older Asthmatics.
Keywords: Asthma, Depression.
SUMMARY:
This longitudinal study of older asthma patients examines the role of Major Depression (MD) in asthma outcomes, and identifies two potential pathways linking them- systemic and airway inflammation, as well as illness and medication beliefs which may lead to different Self-Management Behaviors (SMB).
ABSTRACT
This longitudinal study examines older asthma patients at six month intervals over the course of 18 months to detect the presence of Major Depression (MD), inflammatory markers, Self- Management Behaviors (SMB), and to examine asthma outcomes. The first aim of the study is to determine the relationship of MD with airway and systemic inflammation in this population, as well as to evaluate the longitudinal association with outcomes. It is hypothesized that older asthma patients with MD will have increased airway and systemic inflammation; it is also hypothesized that increased airway inflammation in older patients with MD will be associated with worse asthma control over time. The second aim of the study is to establish longitudinal association between MD and adherence to asthma SMB in this population and to identify pathways linking them. It is hypothesized that older asthma patients with MD will have lower adherence to SMB; it is also hypothesized that views of asthma as an acute disease, low self-efficacy for asthma management, heightened emotional responses to asthma (i.e., catastrophizing), and increased concerns about asthma medications will mediate, in part, the influence of MD on SMB.
Music Research Paper - ABSTRACT:
Immigration to America not only influenced, but shaped the sounds of film music. Some of the first studios were founded by immigrants – Paramount Pictures, for example, was founded by a Jewish immigrant. Many composers came to the United States and eventually made their way to Hollywood to work on films. Franz Waxman, Max Steiner, Miklós Rózsa, and Erich Wolfgang Korngold are all examples of immigrants who composed film music. Throughout this paper, through biographical research, I examine their lives and what shaped them to become the composers they were. Specifically, I document how their culture influenced them, what their music sounds like, and the relationship between these two factors.
Additionally, in this paper, I examine the ability of music to express that which the composer wishes to express. I explain how film music can bolster a scene, as well as how moviegoers have come to understand certain troupes or feelings based on the sounds they hear. As certain notes or tones were used to represent different events or feelings in a picture, people grew accustomed to feeling an emotion when they heard a certain sound. I examine this in my analysis of a few film scores by the immigrants mentioned above.
Waxman, Steiner, Rózsa, and Korngold all brought their experiences to America; the cultures of their youth and their memories are portrayed through their music. This paper examines their lives and the musical choices they made in light of their status as immigrants.
Title: Immigration to America and Its Influence on Film Music and its Composers.
Topic: Music History – Early Film Music and the Influence of Immigration on Film Music.
SUMMARY:
Early film music in the United States was largely influenced by immigration. Franz Waxman, Max Steiner, Miklós Rózsa, and Erich Wolfgang Korngold are composers who worked on film music and whose music was influenced by their culture. In this paper I examine these individuals, study the choices they made in the music industry in light of their immigration statuses, and analyze some of their music.
Yeshiva College, Yeshiva University,
Class of 2024
Title: A Study of interaction between KRAS and SMARCA4 (Brg-1) protein in Human colorectal carcinoma cell lines.
Topic: Biology.
SUMMARY:
The aim of this experiment was to determine if the oncogene KRAS binds to and regulates SMARCA4 function. It was found that in the Brg-1 knocked-down cell lines PRMT5 was upregulated and KRAS3 was downregulated, and so it would appear that the oncogene KRAS binds to and regulates SMARCA4 function.
ABSTRACT:
The aim of this experiment was to determine if the oncogene KRAS (Kirsten rat sarcoma viral oncogene homolog) binds to and regulates SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) function. We used the human colorectal cancer cell lines HKE3, a KRAS wt, and HCT116, a KRAS mutant cell line. Brg-1 shRNA was applied to knock down SMARCA4, and knock down of gene was confirmed by western blot. Quantification of multiple gene's expression was performed by qRTPCR in knocked down cells compared to wide type. It was found that in the knocked-down cell lines, PRMT5 was upregulated and KRAS3 was downregulated. It would appear from the results that the oncogene KRAS does bind to and regulate SMARCA4 function." Our hypothesis could help create a SMARCA4 targeted therapy for colorectal cancers expressing KRAS.
ABSTRACT:
Psychedelic research on psychedelic drug treatment has recently gained a renewed interest in the field of mental health as a potential treatment for a variety of disorders including anxiety, depression, and PTSD. Minimal research exists studying the efficacy of psychedelic-assisted therapy (PAT) in the treatment of Eating Disorders (ED), a disorder that is so difficult to treat and affects the lives of so many people. This paper explores the current research on the use of psychedelics in the treatment of eating disorders, including anorexia nervosa, bulimia nervosa, and binge eating disorder. The mechanisms behind the potential effectiveness of psychedelics in treating eating disorders will be examined, as well as any potential risks or limitations of this approach. Ultimately, this paper aims to provide a comprehensive review of the current literature surrounding the use of psychedelics in the treatment of eating . The findings suggest that, although further research is necessary, there is reason for optimism regarding the future of Eating Disorder treatment. PAT provides an outlet to reframe ED patients’ minds and habits and create new pathways that can be beneficial in treatment. Further research should address concerns such as cost, effectiveness, and use of control groups. There is hope that more findings will emerge and PAT may be the next emerging treatment for EDs.
SUMMARY:
The entire world is talking about psychedelics. Which one is the most harmful? Which one is the most common amongst college kids and what are we going to do about it? Or which one is going to help us have the best time at the rave? The world of psychedelic research is taking a different stance to explore these substances. This paper explores the use of various psychedelics as a potential treatment for eating disorders. The hypotheses are based on previous research and the connections that eating disorders have to other disorders that have been treated with psychedelics as well as overlap between eating disorder symptoms and psychedelic reactions.
This research paper received the Monis and Chaya Zuckerman Memorial Award for best research paper in Jewish History (May 2023).
Title: “Uncovering an Antisemitic Past: Jewish Integration to Costa Rica from 1930-1970.”
Keywords: Jewish, Costa Rica, Discrimination, Nationalism, Antisemitism, Xenophobia, Diaspora, Immigration.
ABSTRACT:
During the 20th century Costa Rica experienced a mass migration of European Jews in search of refuge from the increasing poverty, discrimination, violence and religous persecution resulting from World War II. The process of integration of these Jewish refugees — who were often characterized by their nonconformist qualities — to the Costa Rican population that exacted conformity as the price of acceptance, was faced with various challenges. The main contributor to the adversity the Jews faced was the nationalism, xenophobia and fear of competition of Costa Ricans throughout this period. As consequence of this ongoing discrimination, the stories of the Jewish migrants have been systematically absent regardless of the important contributions made by Jews and the crucial roles they have played in the country’s history. Through in-depth investigation and examination of archives, recorded demographics, news reports, interviews and books written by Jewish migrants, this thesis analyzes the difficulties these immigrants encountered during the Jewish diaspora in Costa Rica. Studying the xenophobia Jews experienced in their integration to Costa Rica provides a blueprint on how to prevent other marginalized and immigrant communities from enduring similar discrimination.
Yosef is an author on “Message in a Bottle – An Update to the Golden Record” (https://arxiv.org/abs/2306.01765; to appear in Nature Communications).
Keywords: NASA Jet Propulsion Laboratory (JPL), computers and society, physics and society, physics education.
ABSTRACT:
Communication is an essential asset enabling humankind to forge an advanced civilization. Using approximately 31,000 languages from the Stone Age to our present digital information society, humans have connected and collaborated to accomplish remarkable feats. As the newly dawned Space Age progresses, we are attempting to communicate with intelligent species beyond our world, on distant planets and in Earth's far future. Absent mutually understood signs, symbols, and semiotic conventions, this study, the "Message in a Bottle", uses scientific methods to assess and design a means of communication encapsulating the story of humanity, conveying our thoughts, emotions, ingenuity, and aspirations. The message will be structured to provide a universal yet contextual understanding of modern human society, evolution of life on Earth, and challenges for the future. In assembling this space and time capsule, we aim to energize and unite current generations to celebrate and preserve humanity.
In University of Cambridge’s Fragment of the Month series, Yosef authored “New Pages of Sefer Tagin: JTS ENA 2753.16 and National Library of Russia (NLR) Box N.91” (April 2023).
Keywords: Cairo Geniza, Hebrew manuscript fragments, Sefer Tagin.
ABSTRACT:
Sefer Tagin is an ancient treatise which lists out certain letters, called Otiyyot Meshunnot, that should be written in Torah scrolls in a strange or unusual manner, often by adding little crownlets (Tagin) or whorls to them. Unfortunately, the work was preserved very poorly, and almost no copies of the complete text survive: for example, the editio princeps, published only in 1866, is riddled with errors. So little is known about the text that scholars in the modern day have been forced to try and cobble together some sort of urtext, piecemeal, from bits of manuscript and quotation, but comparing the text between the different textual witnesses that have survived, most of which are relatively late, reveals extraordinary variation. This is what makes Genizah fragments of Sefer Tagin, many of which have been described in previous research, so important. In this paper, two new manuscript pages of Sefer Tagin, JTS ENA 2753.16 and NLR Box N.91, are introduced, transcribed, and analyzed.