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YU News

Holz and Stern Alumni Publish Articles in Oncogene, Clinical Cancer Research

Holz_66186C-37Dr. Marina Holz, the Doris and Dr. Ira Kukin Chair in Biology and professor of biology at Yeshiva University's Stern College for Women, recently published two articles in prestigious scientific journals with her former students and post-docs.

"mTORC1 directly phosphorylates and activates ER[alpha] upon estrogen stimulation" appears in the November 2, 2015 edition of Oncogene and studies the mechanisms underlying hormone-positive breast cancer. The article was co-authored by Stern post-docs Anya Alayev, Rachel Salamon and Rafael Cuesta, as well as Holz's former students, Rose Snyder, Naomi Schwartz and Sara Malka Berger. Snyder and Schwartz are currently pursuing medical studies at YU's Albert Einstein College of Medicine, while Berger is studying for a master's degree in genetic counseling at the Icahn School of Medicine at Mount Sinai.

"ERRα is a marker of tamoxifen response and survival in triple-negative breast cancer" will appear in Clinical Cancer Research and identifies a new population of women with triple-negative breast cancer—cancer that doesn't express hormone receptors—but which does respond to Tamoxifen, an endocrine therapy. This is an especially exciting discovery since women with this type of cancer don't typically respond to Tamoxifen. Co-authors on the article include Schwartz and Alayev, as well as an additional Stern post-doc, Subrata Manna.