Assistant Professor of Chemistry
Dr. Daniel Lim earned his Ph.D. in chemistry from Duke University with Professor Don M. Coltart in 2008, where his research focused on synthetic methodology with an application towards the synthesis of natural products or biologically interesting molecules. Dr. Lim comes to Yeshiva University after completing a postdoctoral fellowship at Yale University with Professor Scott J. Miller, where his research focused on peptide catalysis, with the overlying goal of developing enzyme mimics that draw inspiration from nature, and expand the capabilities of synthetic chemists.
My main goal in choosing my research projects is to create an inspiring laboratory environment and compose a research program with projects that will allow students to evolve into accomplished scientists. Research projects will include the development of synthetic methodology involving asymmetric catalysis and development of new bond forming reactions with applications to the total synthesis of biologically significant natural products. Research students will learn strategies and techniques employed in synthetic organic chemistry, but more importantly, to appreciate the challenges and nuances associated with research in this discipline.
1. Synthesis of Atropisomerically Defined, Highly Substituted Biaryl Scaffolds through Catalytic Enantioselective Bromination and Regioselective Cross-Coupling. Gustafson, J.L.; Lim, D; Barrett, K. T.; Miller, S.J. Angew. Chem., Int. Ed. Engl. 2011, 50, 5125. 2. Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination. Gustafson, J.L.; Lim, D; Miller, S.J. Science 2010, 328, 1251. Highlighted in Chemical & Engineering News, 88 (25), June 21, 2010. 3. Regioselective Asymmetric alpha, alpha -Bisalkylation of Ketones via Complex Induced Syn-Deprotonation of Chiral N-Amino Cyclic Carbamate Hydrazones. Wengryniuk, S.E.; Lim, D.; Coltart, D. M. J. Am. Chem. Soc., 2011, 133, 8714. 4. Development of a Strategy for the Asymmetric Synthesis of Polycyclic Polyprenylated Acylphloroglucinols via ACC Hydrazones: Application to the Total Synthesis of (+)-Clusianone. Garnsey, M. R.; Lim, D.; Yost, J. M.; Coltart, D. M. Org. Lett. 2010, 12, 5234. 5. A Simple and Efficient Method for Asymmetric alpha-Alkylation and alpha, alpha-Bisalkylation of Acyclic Ketones via Chiral N-Amino Cyclic Carbamate Hydrazones. Lim, D.; Coltart, D. M. Angew. Chem., Int. Ed. Engl. 2008, 47, 5207. Highlighted in Chemical & Engineering News, 86(24), June 16, 2008.
Wilf campus - Belfer Hall